NeuroLogic: Fundamentals

EEG Fundamentals

Welcome

Orientation

Learn how cortical activity becomes a scalp signal, how montages display it, and how to read and report an EEG. Work through the lessons in order or use Contents to review a topic.

Course topics

Start with Next. Each topic combines an explanation, a model or clinical example, and a short check. You can revisit any lesson from Contents.

From cortex to channel

Core Concept

Follow five steps from cortical current to recorded channel. This sequence explains polarity, montage subtraction, and the limits of scalp localization.

  1. Source population: Synaptic currents create graded postsynaptic potentials in cortical neurons. Single axonal action potentials are too brief and spatially scattered to dominate routine scalp EEG.
  2. Open field: Thousands of similarly oriented pyramidal cells must be active with enough synchrony for their extracellular fields to add instead of cancel.
  3. Volume conduction: The summed field spreads through brain, CSF, skull, and scalp. This passive journey attenuates and spatially blurs the signal; it does not create a new rhythm.
  4. Electrode potential: Each scalp electrode samples the local extracellular potential produced by the mixture of fields that reaches it. An electrode has no meaningful absolute voltage by itself.
  5. Channel difference: The amplifier displays Input 1 minus Input 2. The waveform therefore belongs to a channel (a comparison), not to either electrode alone.
Synchrony makes the signal
Synchrony, not a single conductor

A crowd is quiet at a distance when everyone speaks independently and loud when many people clap together. Cortical synchrony likewise emerges from interacting thalamocortical and intracortical networks; the thalamus is important for several rhythms, but it is not the sole conductor of EEG.

Scalp detection generally requires synchronous activation across several square centimeters of cortex; often-cited estimates begin around 6 cm², but detectability varies with depth, orientation, synchrony, amplitude, and competing background activity.

Cross section showing synchronized aligned cortical pyramidal neurons whose extracellular fields sum and spread through CSF, skull, and scalp to an EEG electrode
Aligned cortical populations generate a cumulative extracellular field; volume conduction carries a blurred, attenuated version to the scalp electrode.

The diagram above traced cortex → extracellular field → volume conduction → electrode. Routine scalp EEG reflects the summed postsynaptic fields of synchronized cortical populations, not individual axonal spikes.

Quick check Follow the diagram from cortex to scalp. Which signal contributes most directly to routine scalp EEG?

Why EEG sees synapses, not single-neuron spikes

Core Concept

Routine scalp EEG is dominated by the extracellular fields of synchronized cortical postsynaptic currents. Duration helps explain temporal summation, but spatial alignment, cancellation, source extent, depth, and the competing background also determine detectability.

Predict: keep the cells aligned and increase their timing spread. Which event loses more of its summed peak: a brief biphasic action-potential-like event or a longer postsynaptic event?

The model below shows how timing and orientation change a combined field. Its 24 cells stand for a larger population; the signal uses relative field units, not membrane voltages.

Left: a stadium crowd each doing something different, with a jagged low-amplitude trace beneath, labeled random noise. Right: the same crowd moving in unison, with a smooth high-amplitude sine wave beneath, labeled synchronized signal.
Same number of people on both sides. Only the timing differs.

Choose an event, then spread its timing. Notice how much activity still overlaps.

Snapshot: at the combined peak
Brighter cells are more active. The dotted line links their activity to the same moment on the trace. Replay slows 200 ms into eight seconds; the vertical scale stays fixed.
Event duration
Combined peak

Try 5 ms of timing spread, then flip half the cells. Timing dispersion and geometric cancellation are different mechanisms. Watch what each does to the combined signal.

Why routine scalp EEG is dominated by postsynaptic fields

Brief axonal events have unfavorable temporal and spatial summation at the scalp. A quiet trace does not imply silent neurons. Likewise, synchrony is not itself epileptiform: alpha rhythms and sleep graphoelements also reflect organized population activity.

Two meanings of “spike.” A single axonal action potential lasts about 1 ms. An EEG spike is a 20–70 ms scalp waveform generated by a population of neurons. The terms describe different levels of physiology.

From ion flow to EEG polarity

Biophysics

Start with the extracellular space, because that is where the EEG electrode listens. A sink is a membrane region where conventional positive current enters the neuron. Removing positive charge makes the nearby extracellular space relatively negative. A source is the return-current region, where positive current leaves the cell and the extracellular space becomes relatively positive.

Pyramidal cells are aligned perpendicular to the cortical surface. When many of them activate together, the sink and source fields add as an open field. Move the synaptic current from the apical dendrites to the soma and the dipole flips, even though the cellular event can still be excitatory.

Interactive current field

Move the synapse, then follow the charge

Synaptic current and the surrounding field The highlighted synapse creates a local sink or source. The scalp field and EEG deflection update with the selected synaptic event and location. Scalp electrode + Active synapse Negative sink Return current Positive source Green arrows: conventional current
Result at the scalp

EEG deflection

Relative negativity is displayed upward Negative → up

Compared with a fixed, quiet reference.

Schematic shape, not a measured voltage.

At the synapseNegative extracellular sink
Directly aboveRelative negativity
DisplayUpward deflection
About this model

This figure represents an aligned population of pyramidal cells, with a fixed quiet reference. The return current is distributed across the membrane; its arrows show a simplified circuit.

The EPSP example uses inward Na+ current. The IPSP example uses inward Cl− current at a mature, hyperpolarizing synapse. Inhibition depends on ionic driving force and conductance, so polarity alone does not identify excitation, inhibition, or a neurotransmitter.

Apical EPSPsuperficial sinknegative, displayed up
Deep EPSPdeep sinksurface positive, displayed down
Apical IPSPsuperficial sourcepositive, displayed down
Deep IPSPdeep sourcesurface negative, displayed up

Keep the order straight: identify where current crosses the membrane, decide whether the nearby extracellular space is a sink or source, determine the dipole orientation, and only then predict the scalp polarity. Clinical EEG displays relative negativity upward.

Use the polarity rules and ion lab above: inward positive current at a superficial synapse removes positive charge from the nearby extracellular space, leaving relative negativity at the electrode.

Quick check Positive current enters a superficial apical dendrite during an EPSP. What does the nearby extracellular electrode sample?

Dipole orientation and scalp maxima

Physics

Pyramidal cells stand perpendicular to the cortical surface, and the cortex is folded, so the fold decides which way the dipole points. A cell on a gyral crown points its dipole up at the scalp. A cell on a sulcal wall points sideways. Orientation changes the scalp field. The field maximum alone cannot uniquely determine the generator.

Try these three comparisons:

  1. Change orientation: select Radial, Oblique, then Tangential. Watch where the largest field moves and compare the Electrode overhead reading.
  2. Change depth: return to Radial and increase Source depth from 1.0 to 2.0. Watch the curve and the Peak strength reading.
  3. Compare two sources: reset depth to 1.0, then toggle Add an opposing source. Compare the field’s strength and shape with one source versus two.

How the cortex sets orientation

Radial · toward the scalp

The highlighted cell turns with the cortical fold. Its long axis stays perpendicular to the local surface.

Where the scalp field is largest

Blue −, upward · Red +, downward

The ring marks the electrode directly above the first source. The curve shows position, not time, on a fixed field scale.
Electrode overhead
Largest field
Peak strength
About this model

The fold illustrates orientation; the depth slider separately controls source depth in relative units. The added source has equal strength, opposite orientation, and a fixed separation of 0.4 units. It is shown in the field panel.

Point dipoles in a homogeneous conductor, with zero reference at infinity. Field units are relative, not microvolts; the radial peak at depth 1 is 100 units. Electrode colors show polarity. Source symbols are schematic. A scalp maximum cannot uniquely locate a cortical source.

At 90° in this model: the field is zero directly above the source, with opposite-polarity peaks on either side. Neither peak alone locates the underlying cortical generator.

Why deep sources hide

Greater depth reduces and broadens the field in this model. Opposing cortical populations can partially or completely cancel, depending on their relative timing, strength, and geometry. Orientation and depth are separate variables; neither alone determines scalp detectability.

EEG and MEG provide complementary views. In a spherical approximation, MEG is preferentially sensitive to tangential sources, while EEG detects radial and tangential components. Real anatomy and noise also affect both recordings.

Once the field reaches the scalp, the next task is naming the electrode sites that sample it.